Keep track of Closely (one)bortezomib will enhance the amount or effect of finerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Acute advancement or exacerbation of congestive heart failure and new onset of lowered remaining ventricular ejection portion have occurred
nifedipine will enhance the amount or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
fluvoxamine will enhance the amount or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
rifabutin will reduce the extent or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
The therapeutic dose of bortezomib is individualized in Each individual affected person to forestall overdose. Lethal outcomes transpired in individuals following the administration of more than twice the advisable therapeutic dose of bortezomib. The symptoms from overdose provided the acute onset of symptomatic hypotension and thrombocytopenia. As there is no acknowledged antidote for bortezomib overdosage, monitoring of essential symptoms and appropriate supportive treatment ought to be initiated when drug overdosage is suspected.
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tecovirimat will raise the level or influence of bortezomib by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Tecovirimat is usually a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse outcomes if coadministered with delicate substrates of those enzymes.
bortezomib will improve the level or influence of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
conivaptan will Atpenin A5 increase the level or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
butabarbital will lower the extent or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
apalutamide will decrease the extent or effect of bortezomib by influencing hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medicines which can be CYP2C19 substrates can lead to lower publicity to those medicines.
griseofulvin will reduce the level or impact of bortezomib by affecting hepatic/intestinal enzyme Imidacloprid CYP3A4 metabolism. Small/Significance Unidentified. Warning is encouraged with concurrent use.
Bortezomib incorporates a slim therapeutic window; Retene an overdose can arise when doubling the dose. The affected person will usually existing with marked thrombocytopenia and hypotension, that are very difficult to reverse.